After developing debilitating migraines at 37, Pia Mancini knows what it’s like to sense that something has changed and still be told you’re too young or your labs are fine. Spending years looking for answers, before learning that perimenopause could be part of the picture. That experience became the starting point for Give Zero, and it’s what drew us to this conversation: her determination to help other women understand their hormonal health and feel heard.

As interest in women’s hormone health continues to grow, so does the conversation around skin and perimenopause. In this conversation, Dr. J breaks down what happens to skin during perimenopause, why so many women feel caught off guard by these changes, and how aesthetic care is evolving to better support this stage of life. Her perspective offers a new way to understand skin, aging, and the changes women experience.

Menstruation has long been shaped by silence, stigma, and systems designed to keep women disconnected from their own bodies. For filmmaker Rebecca Snow, those forces became impossible to ignore while directing Pandora’s Box, a documentary exploring menstrual inequity and the cultural taboos that continue to shape cyclical health. In this conversation with Two Moons, she reflects on why Pandora’s Box was created to “fling open the lid” on menstrual stigma, why silence around women’s biological transitions is structural rather than accidental, and how female-led storytelling can shift who controls the narrative around women’s bodies.

A nurse practitioner with more than 25 years of clinical experience, Cynthia has become one of the leading voices in the perimenopause space through her podcast, writing, and widely viewed TEDx talk on intermittent fasting. But this conversation moves beyond wellness trends and into the mechanics of what actually changes in midlife: the decline in microbial diversity, the role of the estrobolome in estrogen metabolism, the relationship between cortisol and intestinal permeability, and why chronic inflammation so often sits underneath hormonal symptoms.